Engineering Antibodies for Cancer Immunotherapy

Engineering Antibodies for Cancer Immunotherapy

The immune system and its underlying connections play an important role in many diseases such as cancer, fibrosis and heart failure. In cancer, researchers are investigating immunotherapies that activate the body’s immune system to fight and destroy tumors. Bryan (Bo) C. Barnhart, senior director, Immuno-Oncology, explains why scientists are targeting immune system pathways to treat cancer, how antibodies can be engineered to act most effectively and where immunotherapy may be headed in the future as more treatment targets emerge.